Top MDMA Supplements to Improve Your Comedown

Top MDMA Supplements to Improve Your Comedown

After a night of indulging in some molly, you might find yourself dreading the comedown. But did you know that there are supplements that can help you cope with the comedown? And, have you heard of people using biohacks such as magnesium glycinate to reduce clenching and vitamin C to reduce brain fog?

There may be plenty of supplement suggestions to improve your MDMA experience, but the real question is, do they work?

This article will shed some light on whether or not supplements counter the short-term after-effects of MDMA, as well as some other tips to make your MDMA comedown a little bit easier

What Goes Up Must Come Down

3,4-methylenedioxymethamphetamine, aka MDMA, is a synthetic drug that has potent hallucinogenic properties. In its tablet form, Ecstasy has for a long time been a popular recreational drug, although it might not always contain MDMA in it. Molly is the street name of MDMA.

The effects of Ecstasy usually kick in 45 minutes after it has been ingested. A dose of 80-125mg will last for an average of 3-6 hours. During this period, the user will be reeling in euphoria. Even though they might have an altered state of mind, they will feel present in the world. 

Unfortunately, as MDMA wears off, it causes a reduction in serotonin levels. Since serotonin is the “feel-good hormone”, the user may go into a depression that can last for up to a week when it is reduced. For this reason, it is highly recommended to avoid taking MDMA too often, and it’s also a good idea to consider supplements to help counter the adverse effects. 

Tips to Improve an MDMA Comedown

As well as supplements, here are a few precautionary tips to forestall a lousy comedown after consuming MDMA:

  • Hydrate, hydrate, hydrate, but don’t overdo it. 500ml prior, during, and after should be sufficient.
  • Boost your electrolyte levels, as mentioned above. 
  • Avoid mixing MDMA with other drugs and alcohol, as stated above.
  • Eat plenty of fruits and veggies before indulging. Eating helps you regain your energy. Even if you don't have an appetite, especially during a comedown, it's recommended to eat, so consuming a balance of hearty carbs, fats, and proteins seems the most sensible choice.
  • Keep your body temperature within the normal range.
  • Take a break of 3-5 weeks between rolls to recover your energy.
  • Spend the day in bed and remind yourself that it's temporary. Just bear in mind that it will be over soon and you'll make it through. For this reason, it's also better to stay in bed and get a good sleep. 

These were the basic precautions you should take to ease your comedown. Yet, sometimes they're not helpful enough when you're experiencing an MDMA comedown. When that's the case, taking supplements might be the best choice to take care of yourself. Read on to find out the top MDMA supplements to consider before, during, and after an MDMA comedown. 

Important Note

In most cases, MDMA supplements should not be taken together with MDMA. To As a thumb rule, only water (250ml) and electrolytes (250ml) are safe to take with MDMA. So, bear that in mind. 

Top MDMA Supplements to Consider to Improve Your Comedown

MDMA supplements are not exclusive to the MDMA market. They are supplements that can be used in different settings and are found in most stores that stock supplements. Some supplements can be taken before the trip to amplify the effects of MDMA. The ones listed below, as stated above, are intended to reduce adverse effects that are associated with an MDMA comedown. 



The body uses magnesium to get rid of excessive glutamate. High levels of glutamate cause “excitotoxicity, “ which damages brain cells and results in jaw clenching, teeth grinding, and tense muscles. Consuming magnesium before taking an MDMA trip might help you enjoy the euphoric effects without having to endure the muscle-related adverse effects such as jaw clenching.

Magnesium is an MDMA supplement that is widely used by the gay community. It allows them to enjoy sensual activities under the influence of MDMA.

How to Take Magnesium Supplements for MDMA Comedown

For starters, you should take one capsule with food. Alternatively, you can take 100-200mg of magnesium, 6-12 hours before the comedown, 1 hour before the comedown, and during the comedown.

Alternatively, you can just eat cucumbers or, at the very least, implement them into your daily diet since they are a great source of magnesium.


5-HTP for MDMA comedown

Some MDMA users consume 5-HTP to help with their comedown. It has been suggested that 5-HTP might help balance serotonin levels due to the use of MDMA. The thing with 5-HTP is that unlike the other supplements in this list, the Food and Drug Administration (FDA) has not yet approved it. Yet, there’s evidence that this supplement might effectively treat a number of symptoms, including mood and sleep disorders and anxiety, common during an MDMA comedown.

How to Take 5-HTP Supplements for MDMA Comedown

According to studies, taking a 5-HTP supplement of 50-300mg per day might improve symptoms of depression and insomnia, as well as headaches. With this information on hand, taking 5-HTP before and after the comedown seems like a good idea.

That said, if you’re taking medications that increase serotonin levels, like antidepressants, you’d want to avoid 5-HTP. So, keep that in mind before consuming this rave recovery pill, alongside the other supplements, Vitamin C and magnesium included.

Grape Seed Extract

Grape seed extract for MDMA comedown

Grape seed extract is loaded with vitamin E and flavonoids, which are potent antioxidants. They prevent oxidative stress, which is responsible for nasty MDMA hangovers.

How to Take Grape Seed Extract Supplements for MDMA Comedown

Aim to take one capsule with food, and 100mg of grape seed extract, 6-12 hours before the comedown, 1 hour before the comedown, and during the comedown.

N-Acetyl-Cysteine (NAC) 

N-Acetyl-Cysteine (NAC) for MDMA comedown

This supplement is a bio-product of glutathione which is the body’s primary natural antioxidant. Taking it might help protect the brain from oxidative stress, which is the leading cause of nasty hangovers.

How to Take N-Acetyl-Cysteine (NAC) Supplements for MDMA Comedown

Take two capsules with lunch. Do not take it together with the MDMA at the same time.

Vitamin C

Vitamin C for MDMA comedown

Vitamin C is a readily available antioxidant that can be used to smooth out an MDMA comedown. These free radical scavengers come in chewable tablet form, making them ideal for pairing with your MDMA intake.

How to Take Vitamin C Supplements for MDMA Comedown

Opt for 1 to 2 tablets with lunch or dinner, and 500-1000mg of Vitamin C 1 before the comedown and during the comedown. Taking Vitamin C after the comedown is not recommended, as you should go for melatonin, instead (more on that later on).


Melatonin for MDMA comedown image

Besides regulating your sleep-wake cycle, Melatonin is a powerful antioxidant. Some users find this supplement very helpful for MDMA comedowns.

How to Take Melatonin Supplements for MDMA Comedown

It is recommended to take a small dose of two pills (around 5-10mg) after the comedown, 30 minutes before bed.


Using enhancing supplements to experience your MDMA ride seems like a smart way to enjoy the trip and reduce the after-effects of each high. Sure, if you take a bad Ecstasy or you have a more severe side effect, supplements won't be much of a help (and you must seek medical help), but in most cases, enhancing substances like magnesium, vitamin C, or grape seed extract can make a difference. 

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